I just recently upgraded to a new desktop and run SimCity on Windows 10 Creators update, works well. Best it's ever looked for me. I was running it on low - med settings on a Vista Home Premium laptop, and now I've got a GTX 1070 and can run on high - ultra.
A couple of caveats: Set Origin.exe and SimCity.exe shortcuts to "Run As Administrator". Make sure you have the newest drivers for your video card; there were tons of issues with a couple of Radeon drivers, but that's fixed with the latest ones now. The program does not play well with super high def. I'm running 1920 x 1080 fine. I have heard of issues with 4k settings and occasionally dual monitors, so if you have any issues, fiddle with graphic settings first.