Try this:
- Log out of SimCity and Origin.
- Navigate to your SimCity game folder; the default location is C:\Program Files (x86)\Origin Games\SimCity\
- Delete the SimCityUserData folder (don't worry, the game will recreate it when you log in).
- Set your SimCity and Origin shortcuts to "Run As Administrator" (right-click the shortcut, choose Properties, Compatibility tab, check box "Run As Administrator"
- Run SimCity again
If this doesn't work, please start a new thread and let us know whether you're running on PC or Mac, your OS version, and any error messages you get. Good luck!