I had tried to uninstall and reinstall multiple times on High Sierra without any luck, but on the latest update on my devbeta of 10.14 I got some strange error messages when I tried to launch the game, it for instance asked for permission to controll the computer. I therefore decided to give it a try to just clean the install and reinstall and BOOM.
But if you have some important saves you want to keep, there are actually ways to back them up when you uninstall and reinstall. Just google it! (: I needed to do that when I struggled with some defective mods on the game before.
UPDATE: I have now played the game without any issues on max resolution for some time!