Hi
Basics - Make sure graphics drivers and Windows OS are patched and updated to newest versions. If you have Nahimic 2 from MSI - this is an audio management program that comes with MSI motherboards - disable or uninstall it. Nahimic 2 is known to cause this issue.
Disable Origin in-game In Origin main menu, right-click SimCity icon, Game Properties, check the box that says "Disable Origin In-game"
Run in Windows 7 or 8 compatibility mode - right-click SimCity shortcut; choose Properties > Compatibility tab > Check the box to run in Win 7 or 8 compatibility mode
Monitor Settings - SimCity does not work with dual monitors, so set it to use one only. Also, no higher than 1080p resolution (no 4k)
No Mods - if you have any installed, uninstall them
Exit SimCity and Origin. Delete the entire SimCityUserData folder - default location is C:\Program Files (x86)\Origin Games\SimCity\SimCityUserData Then launch Origin, right-click SimCity icon and choose to "Repair Game". Once the repair completes, launch SimCity again.
Definitely post back and let us know whether something worked. If it still won't run, reply back with any error messages you're getting and attach a dxdiag report. How to Dxdiag