Hi
Check the following - looks like a lot, but they're really pretty quick and can probably get you running SimCity.
Firewall and Antivirus - Make sure SimCity.exe and Origin.exe are added to exception lists. If you have BitDefender installed, disable it.
Graphics drivers and Windows OS are patched and updated to newest versions
SimCity.exe and Origin.exe - Set them to run "as administrator"
Nahimic 2 from MSI - this is an audio management program that comes with MSI motherboards. Disable or uninstall it. Nahimic 2 is known to cause this issue.
If you still get an error when trying to launch:
Copy Update Files to SimCity folder. Go to Program Files (x86)\Origin Games\SimCity\SimCityUserData\Patches\UpdatedApp Select all files (Ctrl-A) and copy (Ctrl-C). Go to \Program Files (x86)\Origin Games\SimCity and paste (Ctrl-V). Choose to overwrite any files that already exist.
Disable Origin in-game In Origin main menu, right-click SimCity icon, Game Properties, check the box that says "Disable Origin In-game"
Run in Windows 7 or 8 compatibility mode - right-click SimCity shortcut; choose Properties > Compatibility tab > Check the box to run in Win 7 or 8 compatibility mode
Monitor Settings - SimCity does not work with dual monitors, so set it to use one only. Also, no higher than 1080p resolution (no 4k)
Definitely post back and let us know whether something worked. If it still won't run, reply back with any error messages you're getting and attach a dxdiag report. How to Dxdiag